Kidney failure causes a build-up of a toxic substance in the blood. What is that substance?

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Multiple Choice

Kidney failure causes a build-up of a toxic substance in the blood. What is that substance?

Explanation:
When kidneys fail, they can’t remove waste products from protein metabolism. The main nitrogenous waste that builds up in the blood is urea, formed in the liver from ammonia. This accumulation causes uremia and is the classic toxin associated with kidney failure. While creatinine and uric acid also rise with impaired kidneys, urea is the most representative substance described in this context. Glucose is not a waste product and doesn’t accumulate due to kidney failure.

When kidneys fail, they can’t remove waste products from protein metabolism. The main nitrogenous waste that builds up in the blood is urea, formed in the liver from ammonia. This accumulation causes uremia and is the classic toxin associated with kidney failure. While creatinine and uric acid also rise with impaired kidneys, urea is the most representative substance described in this context. Glucose is not a waste product and doesn’t accumulate due to kidney failure.

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